Soluble Receptor for Advanced Glycation End Products (sRAGE) is decreased in patients with Juvenile Idiopathic Arthritis (ERA category) and inversely correlates with disease activity and S100A12 levels

نویسندگان

  • Amita Aggarwal
  • Arpita Myles
  • Vishad Viswanath
  • Yogesh Preet Singh
چکیده

Objectives Membrane bound receptor for advanced glycation end products (RAGE) is over-expressed in response to increasing concentrations of its ligand (eg S100A12) and triggers an inflammatory immune response. Its truncated form sRAGE acts as decoy receptor and competes for ligands thus down-modulating inflammation. Decreased sRAGE levels are associated with rheumatoid arthritis, Sjogren syndrome and Kawasaki disease, however limited data is available in JIA thus we studied its levels in JIA-ERA patients.

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عنوان ژورنال:

دوره 9  شماره 

صفحات  -

تاریخ انتشار 2011